Biological Investigations for integrated surveillance of SARS-CoV-2
Coronavirus (CoV) which are positive-stranded RNA virus surrounded by an envelope, were first identified during the 1960s by using electron microscopy to visualize the distinctive spike glycoprotein projections on the surface of enveloped virus particles.
Coronavirus belong to the family Coronaviridae and are divided into four genera: Alpha-, Beta-, Gamma, and Deltacoronavirus. SARS-CoV (severe acute respiratory syndrome coronavirus), are one among the seven identified human coronavirus which are zoonotic in origin; they cause severe respiratory syndrome and are often fatal. Since the beginning of the epidemic in late December 2019, SARS-CoV-2 has now spread to all continents.
Journal of Biochemistry and Biotechnology publishes novel research on SARS-CoV, as it includes the Biological process of SARS-CoV. Replication and transcription of CoV RNA takes place in the cytoplasm of infected cells. The CoV virion attaches to the host cell receptor via the spike glycoprotein and, depending on the virus strain, the spike mediates fusion directly with the plasma membrane or the virus undergoes receptor-mediated endocytosis and spike-mediated fusion with endosomal membranes to release the viral gRNA into the cytoplasm. Once the positive-strand RNA genome is released, it acts as a messenger RNA (mRNA) and the 5′ end is translated by ribosomes to generate the viral RNA-dependent RNA polymerase polyprotein, termed the viral replicase.
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Journal of Biochemistry and Biotechnology
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