Adult Neurogenesis: Beyond Rats and Mice

Image   Every machine requires regular maintenance and replacement of old, worn out parts. Most biological tissues routinely replace old cells with new ones. Unlike other tissues, the nervous system–being the most complex biological device found in nature–uniquely maintains most of its neurons throughout life and replaces relatively few. It preserves hotspots where it generates new neurons from resident stem cells during adulthood in a process known as adult neurogenesis, which varies among different species in its features, dynamics and regulation. In spite of its wide... Read More

G-protein-coupled receptors

Image G-protein-coupled receptors   G-protein-coupled receptors (GPCRs) are among the largest and most diverse family of proteins in the mammalian genome, which transduce signals as a response to a wide range of stimuli. GPCRs are major targets in drug discovery, as reflected by the fact that they encompass about 50% of current medicinal compounds. In humans, the completed human genome project has led to the identification of over 865 GPCR genes. The diversity of GPCRs is dictated not only by the variety of stimuli that they respond to, but also their partic... Read More

Research on E. coli

Image Research on E. coli E. coli (Escherichia coli), is a type of bacteria that normally lives in your intestines. It’s also found in the gut of some animals. Most types of E. coli are harmless and even help keep your digestive tract healthy. But some strains can cause diarrhea if you eat contaminated food or drink fouled water. While many of us associate E. coli with food poisoning, you can also get pneumonia and urinary tract infections from different types of the bacteria. In fact, 75% to 95% of urinary tract infections are caused by E. coli.... Read More

Forest Genetic Monitoring - Preventing Forests Loss in a Changing Climate

Image Forest genetic resources face a large number of increasing threats. Climate change, air pollution, unsustainable forest management, invasive species, urbanization and forest fragmentation reduce forest biodiversity, may adversely affect genetic diversity and put at threat the future adaptive potential and sustainability of European forests and their ecosystems. Information on relevant changes of a species and/or populations’ adaptive and neutral genetic variation through time caused by management and conservation measures is needed. This information can only be obtained through geneti... Read More

Symptoms and treatment of bacterial infections

Image Symptoms and treatment of bacterial infections   Bacterial disease, any of a variety of illnesses caused by bacteria. Until the mid-20th century, bacterial pneumonia was probably the leading cause of death among the elderly. Improved sanitation, vaccines, and antibiotics have all decreased the mortality rates from bacterial infections, though antibiotic-resistant strains have caused a resurgence in some illnesses. In the early 21st century, tuberculosis, which is caused by Mycobacterium tuberculosis—several strains of which had developed resistance to one or m... Read More

Malignant Hyperthermia

Image Malignant hyperthermia (MH) is a type of severe reaction that occurs in response to particular medications used during general anesthesia, among those who are susceptible. Symptoms include muscle rigidity, high fever, and a fast heart rate. Complications can include muscle breakdown and high blood potassium. Most people who are susceptible are generally otherwise normal when not exposed. The cause of MH is the use of certain volatile anesthetic agents or succinylcholine in those who are suscep... Read More

Epidemiological features of chronic low-back pain

Image Although the literature is filled with information about the prevalence and incidence of back pain in general, there is less information about chronic back pain, partly because of a lack of agreement about definition. Chronic back pain is sometimes defined as back pain that lasts for longer than 7–12 weeks. Others define it as pain that lasts beyond the expected period of healing, and acknowledge that chronic pain may not have well-defined underlying pathological causes. Others classify frequently recurring back pain as chronic pain since it intermittently affects an individual over a... Read More

Infection of mammalian liver by the malaria parasites

Image Malaria parasites are micro-organisms that belong to the genus Plasmodium. There are more than 100 species of Plasmodium, which can infect many animal species such as reptiles, birds, and various mammals. Four species of Plasmodium have long been recognized to infect humans in nature. A disease caused by a plasmodium parasite, transmitted by the bite of infected mosquitoes. The severity of malaria varies based on the species of plasmodium. Symptoms are chills, fever and sweating, usually occurring a few weeks after being bitten. People travelling to a... Read More

Studies of the symptom abdominal pain—a systematic review and meta-analysis

Image Background. Diagnostic reasoning in primary care patients with abdominal pain is a complex challenge for GPs. To ensure evidence-based decision making for this symptom, GPs need setting-specific knowledge about the prevalence, potential risks for diseases and chance of recovery or risk of undesirable courses of disease. Aim. We conducted a systematic review of symptom-evaluating studies on prevalence, aetiology or prognosis of abdominal pain. Methods. We included all studies evaluating the s... Read More

Common mechanisms of pain and depression: are antidepressants also analgesics?

Image Neither pain, nor depression exist as independent phenomena per se, they are highly subjective inner states, formed by our brain and built on the bases of our experiences, cognition and emotions. Chronic pain is associated with changes in brain physiology and anatomy. It has been suggested that the neuronal activity underlying subjective perception of chronic pain may be divergent from the activity associated with acute pain. We will discuss the possible common pathophysiological mechanism of chronic pain and depression with respect to the default mode network of the brain, neuroplasticity ... Read More

Vitamin D and its potential interplay with pain signaling pathways

Image About 50 million of the U.S. adult population suffer from chronic pain. It is a complex disease in its own right for which currently available analgesics have been deemed woefully inadequate since ~ 20% of the sufferers derive no benefit. Vitamin D, known for its role in calcium homeostasis and bone metabolism, is thought to be of clinical benefit in treating chronic pain without the side-effects of currently available analgesics. A strong correlation between hypovitaminosis D and incidence of bone pain is known. However, the potential underlying mechanisms by which Vitamin D might exert it... Read More

Emerging Swine Viruses

Image   Emerging and re-emerging virus infectious diseases continue to challenge diagnostic, prevention and control strategies in the swine industry. Over the past decade, a number of emergent swine viruses have been identified in the global swine population. These viruses can be categorized into three groups: 1) re-emerging swine viruses, such as porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV), pseudorabies virus (PRV), and porcine circovirus type 2 (PCV2), which cause economically important diseases in ... Read More

High-Sensitivity Cardiac Troponin-T and I

Image The primary objective was to directly compare the prognostic accuracy of hs-cTnT versus hs-cTnI for the prediction of death in patient with pneumonia.   The prognostic accuracy of high sensitivity (hs)-cTnT and hs-cTnI was directly compared among patients presenting with dyspnea to the emergency department and centrally adjudicated by two independent experts to have pneumonia. Blood samples for the blinded measurement of hs-cTnT and hs-cTnI, as well as NTproBNP were obtained at ED presentation. CURB-65 was calculated as the multivariate risk score recommended in cur... Read More

A Guide for Pain Management in Low and Middle Income Communities. Managing the Risk of Opioid Abuse in Patients with Cancer Pain

Image Most patients who present with cancer have advanced disease and often suffer moderate to severe pain. Opioid therapy can be safe and effective for use in cancer patients with pain, but there are rightful concerns about inappropriate opioid use even in the cancer population. Since cancer patients live longer than ever before in history (and survivors may have long exposure times to opioid therapy), opioid misuse among cancer patients is an important topic worthy of deeper investigation. Cancer patients with pain must be evaluated for risk factors for potential opioid misuse and aberrant drug... Read More

Agency over Phantom Limb Enhanced by Short-Term Mirror Therapy

Image Most amputees experience phantom limb, whereby they feel that the amputated limb is still present. In some cases, these experiences include pain that can be alleviated by “mirror therapy.” Mirror therapy consists of superimposing a mirrored image of the moving intact limb onto the phantom limb. This therapy provides a closed loop between the motor command to the amputated limb and its predicted visual feedback. This loop is also involved in the sense of agency, a feeling of controlling one’s own body. However, it is unclear how mirror therapy is related to the sense of age... Read More

Teledermatology

Image Teledermatology Dermatology is an independent clinical secondary discipline established on the basis of cognitive features. With the emergence of digital technology, remote transmission technology and internet technology, dermatology has become the easiest discipline to integrate with these technologies and establish clinical application scenarios. At present, the development of skin imaging technology (dermoscopy, reflectance confocal microscopy, etc.), teledermatology and artificial intelligence has profoundly and comprehensively changed the characteri... Read More

Brain Evolution: Clues from Aquatic Organisms

Image This Research Topic is proposed to gain insight into the evolution of brain structure, function, and physiology by exploring the neuroanatomy and neurophysiology of aquatic organisms. It aims to collect more information on 1) the evolution of brain structures and the interpretation of their functional significance, 2) the origin of diseases and the evolution of healing processes, and 3) to expand knowledge about the fundamental mechanisms of the nervous system. Aquatic organisms, either vertebrates or invertebrates, living in marine or freshwater environments, show considerable va... Read More

BIOMATERIALS THAT ENGINEER INFECTION IMMUNITY

Image Gene-based nucleic acid vaccines are capable of eliciting protective immunity in humans to persistent pathogens, e.g., HIV, malaria, and tuberculosis, for which conventional protein/peptide vaccines have failed. Recent identification and characterization of genes coding for tumor antigens has stimulated the development of nucleic acid-based cancer vaccines. With increasing life expectancy in high-income countries and newly emerging infections in low-income countries, new technologies are required to address changing vaccine needs. Nucleic acid vaccines have the potential to address these ne... Read More

The Walker 256 Breast Cancer Cell- Induced Bone Pain Model in Rats

Image The majority of patients with terminal breast cancer show signs of bone metastasis, the most common cause of pain in cancer. Clinically available drug treatment options for the relief of cancer-associated bone pain are limited due to either inadequate pain relief and/or dose-limiting side-effects. One of the major hurdles in understanding the mechanism by which breast cancer causes pain after metastasis to the bones is the lack of suitable preclinical models. Until the late twentieth century, all animal models of cancer induced bone pain involved systemic injection of cancer cells into anim... Read More

Advances in the Study of Neotropical Fungi

Image The Neotropical biogeographic realm or Neotropic is considered a diversity hotspot for well-studied terrestrial taxa, such as amphibians, reptiles, birds, mammals or plants; however, knowledge regarding fungal diversity and distributions is still scarce. During the last years, using morphological and molecular approaches, new fungal species have been described but the presence of cryptic species or species complexes has frequently led to overestimated geographic distributions of certain taxa. This Research Topic welcomes outstanding contributions addressing the taxonomy, diversity, evolutio... Read More

Animal-Mediated Dispersal in Understudied Systems

Image Animals disperse smaller organisms by ingesting, transporting and egesting propagules such as plant seeds, fruits, small invertebrates and algae (internal transport), or by carrying propagules attached to their exterior (external transport). Animal-mediated dispersal is generally well studied, but most previous work focused on only a handful of species networks. For example, seed dispersal by frugivorous birds and mammals, scatterhoarding by small mammals, seed dispersal by ants, and dispersal of grass seeds by large herbivores have been investigated in much detail. In contrast, ... Read More

Semaphorin 3A: A Potential Target for Low Back Pain

Image Low back pain is a common disorder. Pathological innervation and intervertebral disc degeneration are two major factors associated with this disease. Semaphorin 3A, originally known for its potent inhibiting effect on axonal outgrowth, is recently found to correlate with disease activity and histological features in some skeletal disorders. Based on its effects on innervation and vascularization, as well as enzyme secretion, we presume that semaphorin 3A may act as a potential target for low back pain. Hypothesis: Based on the effects of semaphorin ... Read More

A possible role of the locus coeruleus in complex regional pain syndrome

Image Heightened sensitivity to painful stimulation commonly spreads from the affected limb to the ipsilateral forehead in patients with complex regional pain syndrome (CRPS). In addition, acoustic startle evokes greater auditory discomfort and increases in limb pain when presented on the affected than unaffected side. In contrast, limb pain ordinarily evokes analgesia in the ipsilateral forehead of healthy participants, and acoustic startle suppresses limb pain. Together, these findings suggest that hemilateral and generalized pain control mechanisms are disrupted in CRPS, and that multisensory ... Read More

The Physiology of Bone Pain. How Much Do We Really Know?

Image Pain is associated with most bony pathologies. Clinical and experimental observations suggest that bone pain can be derived from noxious stimulation of the periosteum or bone marrow. Sensory neurons are known to innervate the periosteum and marrow cavity, and most of these have a morphology and molecular phenotype consistent with a role in nociception. However, little is known about the physiology of these neurons, and therefore information about mechanisms that generate and maintain bone pain is lacking. The periosteum has received greater attention relative to the bone marrow, reflecting ... Read More

Schistosomiasis

Image   Schistosomiasis is an acute and chronic parasitic disease caused by blood flukes (trematode worms) of the genus Schistosoma. Estimates show that at least 229 million people required preventive treatment in 2018. Preventive treatment, which should be repeated over a number of years, will reduce and prevent morbidity. Schistosomiasis transmission has been reported from 78 countries. However, preventive chemotherapy for schistosomiasis, where people and communities are targeted for large-scale treatment, is only required in 52 endemic countries with moderate-to-h... Read More

Chemical Sensors

Image Chemical Sensors Novel chemical sensors are poised to revolutionize fundamental scientific research and our daily lives, as they play a more and more important role in various areas within clinical diagnosis. Nowadays, several definitions of chemical sensors are widely recognized, among which include miniaturized devices that can deliver real- time and on-line information in the presence of specific compounds or ions in complex samples. They are also defined by IUPAC as devices that transform chemical information, ranging from the concentration of a specific sampl... Read More

Medical 3D printing

Image Medical 3D printing Medical 3D printing has been gaining attention from the scientific community with an increasing number of publications reported in the literature in the past years. Steady technological advances allow the manufacturing of 3D parts using materials as diverse as polymers, metals, ceramics and biomaterials, thus enabling a wide spectrum of applications. On the one hand, 3D printed parts are used to create anatomical models for planning complex surgical or interventional procedures, for advanced medical education and for R&D of novel surgical t... Read More

Amphibian-Microbial Symbioses and their Ecology

Image Symbiotic interactions between microorganisms and animals are ubiquitous in nature. Recent studies in amphibians have identified symbiotic bacterial communities that play a relevant role protecting the host against pathogens such as Batrachochytrium dendrobatidis, Bd. Many of the bacterial symbionts of amphibians that have been isolated to date produce antifungal metabolites with the capacity to inhibit Bd in vitro and in vivo. These findings have led to the development of probiotics as a promising strategy against chytridiomycosis, the disease caused by Bd, which has caused dramatic declin... Read More

Vertebrate Development & Thyroid Hormones Role

Image Thyroid hormones role in development was first suggested in the 18th century when a relationship between goiter and cretinism was found by F.E. Fodere. But it was Rudolf Virchow work in the late 19th century with thyroidectomized animals that clearly demonstrated that goiter led to cretinism. This opened the door to the understanding of TH action on vertebrate development. However given the relative ease by which cretinism could be treated simply by eating animal thyroid gland or iodine supplementation, research into the action of TH on vertebrate development has been lagging. This was furt... Read More

Pharmacological Advance in Ultrasound Guided Pain Medicine

Image In recent years, ultrasound guided intervention has become a mainstream for treatments of musculoskeletal pain. Compared with traditional fluoroscopy guidance, ultrasound has the advantage of being real-time, zero radiation, and capability of differentiating various soft tissues during intervention. Another advantage of ultrasound is its capability of direct assessment of the neural structures. In particular, the use of ultrasound imaging enables researchers to understand the changes of nerve echo texture after pharmacological applications. Advances in ultrasound technology could potentiall... Read More

Biology and Evolutionary History of Mesosaurs

Image Mesosaurs are among the most amazing extinct animals; they are the oldest known reptiles that developed aquatic adaptations, although how terrestrial their ancestors had become remains to be established; they are the only known vertebrates from Gondwana at the Early Permian and they are represented by thousands of well preserved and almost complete skeletons. Mesosaurs were capable of inhabiting cold and salty water bodies resulting from the drought of an originally large inland sea that extended over what is now South America and Africa. So far, mesosaurs are the only tetrapods k... Read More

Emerging Infections and Diseases of Herpetofauna

Image Currently, we are experiencing unprecedented declines in biodiversity around the globe in what biologists have named the sixth mass extinction. Whilst habitat loss and ongoing anthropogenic environmental change are the biggest threats currently facing the natural world, emerging infectious diseases are partially responsible for large scale declines of many different taxa. For example, in bats, the emerging pathogen, Pseudogymnoascus destructans, the causative agent of White Nose Syndrome, has caused the ongoing decline in many bat species in North America. Other vertebrates such as amphibia... Read More

Remote sensing of invasive species

Image Invasive species are increasingly recognized as key factors in the breakdown of ecosystem function, processes, and services, and loss of native biodiversity. The success of invasive species alters the dynamics of other species in the habitat leading to irreversible changes, ultimately with losses of native biodiversity that can impact the stability and resilience of the ecosystem, possibly by loss of functional traits associated with resource capture and decomposition. Invasive plant species are a global problem and the pace of biological invasions requires better early knowledge about the ... Read More

Zika Virus

Image Zika Virus Recent outbreaks of Zika virus infections in South and Central America have led to an urgent need for research on the biological mechanisms and consequences of Zika infections. The local transmission of Zika virus has been reported in more than 50 countries and the situation was declared as a public health emergency of international concern by the World Health Organization, especially due to the possible causal link between Zika virus infection during pregnancy and the occurrence of microcephaly and other congenital malformations. In this Rese... Read More

Use of Microbes

Image Medically indispensable   Microorganisms have a bad reputation. People think they’re bad for our health. When they think of microorganisms, many people think first about fungal infections, cavities, and illnesses like flu, or worse: AIDS and Ebola. But the number of harmful types doesn’t even come close to the number of harmless ones, or the ones that actually support our health.   Thanks to microorganisms, we have antibiotic... Read More

Journal of Cardiovascular Medicine and Therapeutics- An Unique Submission System

Image Journal of Cardiovascular Medicine and Therapeutics is committed to dispersing unique and top-level original research articles, letters, perspectives, opinions, commentaries, case reports, reviews, letter to editor, editorials, and short communications etc. in every aspect of cardiovascular medicine. Journal of Cardiovascular Medicine and Therapeutics is using online Review and Editorial Manager System for quality review process of allied academies. Editorial Manager System is an online submission and review system, where authors can submit manuscripts and track their progress. Re... Read More

Journal of Cardiovascular Medicine and Therapeutics- Manuscript Invitation for Volume 4 Issue 2

Image Journal of Cardiovascular Medicine and Therapeutics is committed to dispersing unique and top-level original research articles, letters, perspectives, opinions, commentaries, case reports, reviews, letter to editor, editorials, and short communications etc. in every aspect of cardiovascular medicine. The segment Cardiovascular Therapeutics is additionally concerned with the identification and validation of biomarkers to either help drug improvement, or permit a stratified medicine approach in patients. Biomarkers may identify with physiological measures,heredity qualities, or any ... Read More

Coding properties in invertebrate sensory systems

Image Invertebrates, as all other animals, rely on sensory input from their biotic and abiotic environment for survival and reproduction. Depending on the importance of a signal for a given species, accuracy of sensory coding might vary from pure detection up to precise coding of intensity, quality and temporal features of the signal. Investing energy in highly sophisticated sense organs and related central nervous processing areas can be of utmost importance in a complex environment and in animals using advanced communication systems. Peripheral and central sensory systems have therefore develop... Read More

Sentience, Pain, and Anesthesia in Advanced Invertebrates

Image Cephalopod mollusks and decapod crustaceans are believed to the most developed and intelligent invertebrates and may be sentient animals. They are legally protected by a number of national and trans-national organizations, such as the European Union. In the proposed research topic we would start by attempting to define sentience/consciousness, probably in relation to what we understand in marine vertebrates, which may be very different from that in land-based forms. Given that many mollusks, including cephalopods, and crustaceans are model animals in neuroscience and species of in... Read More

Mechanisms and New Targets for the Treatment of Chronic Pain

Image Acute pain has a physiological protective role in preventing tissue damage. However, pain can become chronic due to a multitude of pathophysiological states, such as: trauma, inflammation, neural injury, viral infection, cancer, autoimmune diseases and vascular and metabolic disorders. These pathological states can trigger alterations of the pain pathways that can lead to hypersensitivity, and in such circumstances, pain loses its protective role and instead, becomes persistent and debilitating affecting seriously to the quality of life of patients. Chronic pain is one of the most im... Read More

Cytokine Levels in Neural Pain in Leprosy

Image Pain is a frequent symptom in leprosy patients. It may be predominantly nociceptive, as in neuritis, or neuropathic, due to injury or nerve dysfunction. The differential diagnosis of these two forms of pain is a challenge in clinical practice, especially because it is quite common for a patient to suffer from both types of pain. A better understanding of cytokine profile may serve as a tool in assessing patients and  also help to comprehend pathophysiology of leprosy pain. Patients with leprosy and neural pain (n = 22), neuropathic pain (n = 18), neuritis (nociceptive pain) (n = 4), or... Read More

Pain perception in people with Down syndrome: a synthesis of clinical and experimental research

Image People with an intellectual disability experience both acute and chronic pain with at least the same frequency as the general population. However, considerably less is known about the pain perception of people with Down syndrome. In this review paper, we evaluated the available clinical and experimental evidence. Some experimental studies of acute pain have indicated that pain threshold was higher than normal but only when using a reaction time method to measure pain sensitivity. However, when reaction time is not part of the calculation of the pain threshold, pain sensitivity in people wit... Read More

Can Increase In Temperature Kill COVID-19?

Image Can Increase In Temperature Kill COVID-19? Currently the most chronic disease Coronavirus can stay active for 8-10 days on dry surfaces and while it survives in the human body at 37 degree Celsius, they are heat labile like all viruses and are deactivated or destroyed when subjected to heat. The exact threshold temperature to deactivate COVID-19 is still unknown. Coronavirus: COVID-19 virus has now spread across over 110 countries with no known vaccine or cure. There has been a conjecture that increased temperature can kill the virus and... Read More

Two new developments have taken place since the last briefing in Abuja on the coronavirus situation in Nigeria

Image   The first is that a team of researchers from various institutions in Nigeria, including scientists from the Centre for Human and Zoology Virology in LUTH, African Centre for Genomics of Infectious Diseases in Redeemers University and the Nigeria Institute of Medical Research (NIMR) Lagos, combined their efforts to successfully perform the genome sequencing of the coronavirus strain that the index case brought to Nigeria and proved it to be a match with the virus circulating in Italy and Wuhan. This was coordinated by the Lagos State Ministry of Health and NCDC. It is the fi... Read More

“Call for Papers on Journal of Cardiovascular Medicine & Therapeutics”

Image Being a Managing Editor to Journal of Cardiovascular Medicine and Therapeutics, I would like to take this opportunity to introduce one of our peer viewed journal which is dedicated to is committed to dispersing unique and top-level original research articles, letters, perspectives, opinions, commentaries, case reports, reviews, letter to editor, editorials, and short communications etc. in every aspect of ... Read More

Medical Device Connectivity Market Consumption Sales By Type, Product Specifications, Market Research Methodology, Market Forecast To 2023

Image Medical Device Connectivity Market Consumption Sales By Type, Product Specifications, Market Research Methodology, Market Forecast To 2023 Global Medical Device Connectivity Market Report 2019 – Market Size, Share, Price, Trend and Forecast is a professional and in-depth study on the current state of the global Medical Device Connectivity industry. The report also covers segment data, including: type segment, industry segment, channel segment etc. cover different segment market size, both volume and value. Also cover different industries clients in... Read More

Blood Groups in Companion Animals

Image Transfusions in companion animals such as dogs, cats and horses are frequently done in veterinary medicine as life-saving procedures and as part of the treatment protocol of many hematological, coagulation, and immunological disorders. Companion animals have many blood groups and blood types and some blood typing tests are available for their determination. However, many other blood types are suspected to exist and methods for typing are not always readily available. Studies on new blood type and cross matching methods and on epidemiology of blood groups could improve knowledge of... Read More

Nociceptive System

Image Impacts that threaten or indeed compromise the integrity of tissues trigger the development of a defence response, which through the activity of the nociceptive system includes pain. If the noxious impact does not induce tissue damage, the pain, called “nociceptive” pain, ceases within seconds after the impact is withdrawn. In contrast, if tissue damage does occur, a pain experience that usually persists until the injury is resolved and includes two major pathological sensory experiences, hypersensitivity to heat stimuli (i.e. heat hyperalgesia) and/or hypersensitivity to mechan... Read More

Neuroautoimmunity

Image For a long time, resident innate immune cells in central and peripheral nervous system, such as macrophages/microglia and mast-cells, have been considered as contributing players in peripheral neurodegeneration. New evidence seems to indicate that this view represented an underestimation of the role of inflammation in the nervous system, attributing to neuroinflammation a critical role of primary driver in peripheral neuropathies and pain. This is the case for autoimmune neuropathies (i.e. Guillain–Barré syndromes), diabetic neuropathy or traumatic nerve injury. Since neuropath... Read More

Research on Marine Megafauna

Image Marine megafauna are iconic and charismatic. The threatened or endangered status of many species, the great economic importance of some taxa and their frequent role as keystone species in ecosystems has resulted in many becoming flagships for research by both professional and citizen scientists. The body size and mobility of marine megafauna means that their populations tend to be spread across wide ranges, multiple management jurisdictions and national boundaries. In contrast, research efforts are often compartmentalized, separated by both geography and approach. These barriers t... Read More

Biology and Evolutionary History of Mesosaurs, the Oldest Known Aquatic Reptiles

Image Mesosaurs are among the most amazing extinct animals; they are the oldest known reptiles that developed aquatic adaptations, although how terrestrial their ancestors had become remains to be established; they are the only known vertebrates from Gondwana at the Early Permian and they are represented by thousands of well preserved and almost complete skeletons. Mesosaurs were capable of inhabiting cold and salty water bodies resulting from the drought of an originally large inland sea that extended over what is now South America and Africa. So far, mesosaurs are the only tetrapods k... Read More

Exercise and Sports Medicine

Image Exercise and Sports Medicine Exercise is significant to health and well-being. The introduction of exercise and physical activity into daily life promotes health, fitness, strength, endurance, performance, and quality of life. I would like to know your interest and time in submitting an article for the upcoming issue of 2020. You may submit your papers as an attachment to this email or online at: https://www.scholarscentral.org/submission/allied-medical-research.html. How we work: After submis... Read More

Microbiology of Dental Caries

Image Microbiology of Dental Caries Dental caries can be defined as a localised and chemical loss of the tooth structure caused by the metabolic activity of dental biofilm that covers the tooth surface. This loss is reversible, especially in its early stages. The final outcome of dental caries is determined by multiple factors such as saliva, exposure to fluoride, and sugar dietary consumptions, which influence the dynamic balance between the demineralisation and remineralisation processes. Dental caries can be developed in any part of the tooth surface: enamel, dentine or cementum. How... Read More

“Bless Your Heart. Live Smart.”

Image ​​ Journal of Cardiovascular Medicine and Therapeutics is a monthly Open Access Publication. It publishes original research articles, epidemiological studies, new methodological clinical approaches, case reports, design and goals of clinical trials, review articles, points of view, editorials and Images in cardiovascular medicine.   Submitted articles undergo a preliminary review by the editor. Articles being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. ​ Th... Read More

Network meta-analysis of the effectiveness of various drugs in preventing allergic hypersensitivity in patients after anesthesia

Image Network meta-analysis of the effectiveness of various drugs in preventing allergic hypersensitivity in patients after anesthesia Objective: To explore the effect of different drugs on postoperative hyperalgesia in general anesthesia patients. Methods: A randomized controlled trial was conducted to detect the hyperalgesia of patients with general anesthesia from PubMed, Embase, Medline, CNKI and Wanfang databases. The visual analogue scale (VAS) assessment of hyperalgesia patients after anesthesia was extracted as well as... Read More

Nicotine replacement therapy and varenicline: A cohort study in low-income region (Monastir, Tunisia).

Image Nicotine replacement therapy and varenicline: A cohort study in low-income region (Monastir, Tunisia).  Background: Among motivated Smokers, cessation can be performed by Nicotine Replacement Therapy (NRT), or by Varenicline (VAR). We aimed at determining quit rates among two cohorts, treated by NRT or VAR and, at identifying factors associated to quit and relapse delays. Methods: We carried out a prospective cohort study at the smoking cessation center of the University Hospital of Monastir, in Tunisia from April 2009 to January 2012. Results: 1042 active sm... Read More

Submission Open: Journal of Clinical Nephrology and Therapeutics

Image Journal of Clinical Nephrology and Therapeutics publishes the manuscripts that are directly or indirectly based on variegated aspects of clinical nephrology, diabetic nephropathy, pediatric nephrology, renal physiology, renal histopathology, immunobiology, intensive care nephrology, and ischemic nephropathy. Journal of Clinical Nephrology and Therapeutics publishes the manuscripts that are directly or indirectly based on variegated aspects of clinical nephrology, diabetic nephropathy, pediatric nephrology, renal physiology, renal histopathology, immunobiology, intensive care ... Read More

KCa3.1 as a Novel Therapeutic Target for Diabetic Nephropathy

Image Diabetic nephropathy (DN), a devastating complication of diabetes mellitus, is a worldwide health, societal and economic problem. Tubulointersitial fibrosis has been shown to be the final common pathological consequence of almost all forms of chronic progressive renal disease, including diabetic nephropathy. Numerous pathways have been identified in the pathogenesis of this disease, but clinical strategies based on these pathways for the management of diabetic nephropathy remain unsatisfactory, as the number of diabetic patients with nephropathy continues to increase. New treatment modaliti... Read More

Recent trends in Biochemistry and Biotechnology

Image ADF Recent scientific era has witnessed a tremendous progression in the field of medical sciences due to development in allied fields of biotechnology and biochemistry. New techniques are constantly being introduced leading to the production of remarkable and medicinally valuable molecules, to alter hereditary traits of plants and animals, for diagnosis of various diseases and finally finding novel ways to cure them. The advancement made in the field of biotechnology has resulted in the development of a new class of potential drugs. It also helps in cloning and expression of various prophyl... Read More

Inhibition of LIM Kinase Inhibits Cancer Growth

Image The LIM kinase family of serine protein kinases contains two members, LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2). LIMK1 was first isolated from olfactory epithelial cell lines, and LIMK2 from a rat cDNA library using human LIMK1 cDNA as a probe. LIMK1 and 2 are structurally similar and share 50% amino acid homology, human and mouse LIMK1 share 95% amino acid homology. The amino terminus of LIMK contains two double zinc finger LIM domains, followed by a PDZ domain. Both domains are involved in protein-protein interaction. The C-terminus end of the molecule contains the catalytic active ki... Read More

Supportive and Innovative Hands to Improve advancement’s in Cardiovascular Medicines

Image On behalf of the Journal of Cardiovascular Medicine and Therapeutics, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s been ten long years we have started the Journal, now and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of Cardiovascular Medicine and Therapeutics. ... Read More

Innovative Hands to Improve advancement’s in Cardiovascular Medicines

Image On behalf of the Journal of Cardiovascular Medicine and Therapeutics, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s been ten long years we have started the Journal, now and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of Cardiovascular Medicine and Therapeutics. ... Read More

Predictors of Intradialytic Hypertension in Chronic End Stage Renal Dialysis

Image Patients on chronic maintenance dialysis have an alarmingly high mortality of approximately 15-20%. This rate is mainly due to cardiovascular comorbidity and, secondarily in part to the increasing prevalence of changes in blood pressure. These blood pressure changes are the most common complications that occur in these patients, most commonly hypotension, with Intradialytic Hypertension (IDH) occurring second. This single center, hospital based prospective observational cohort, research study investigated on (a) the prevalence of IDH and (b) determine the demographic, clinical profile and m... Read More

Gastrorenal Axis in the Control of Body Sodium Homeostasis

Image Organ to organ communication is important in the maintenance of normal fluid and electrolyte balance and blood pressure (BP). The gastrointestinal tract and the kidney are major organs involved in this process. Neural mechanisms and gut hormones mediate the natriuretic of an oral sodium load. The flow of sodium into the sodium channels of the stomach antrum activates a sequence of events, leading to G-cell-mediated increase in gastrin secretion and its release into the circulation. Of all the gut hormones circulating in the plasma, gastrin is the one that is reabsorbed to the greatest exten... Read More

Pregnancy among Women undergoing Chronic Hemodialysis

Image The pregnancy is told as a rare event among End-stage Renal Disease (ESRD) women undergoing chronic Hemodialysis (HD). This is mainly due to ESRD to be considered per se as a powerful method of contraception and sexual dysfunction is higher in women undergoing HD likely as a result of the cumulative effects of depression, fatigue, altered body image, medication side effects, and premature menopause, and the gestation in these women is frequently associated with poor fetal outcomes. However, in the last years the number of gestations among patients undergoing HD is increasing exponentially a... Read More

To Collaborate Scientific Professionals around the World- Cardiology

Image Cardiology is an important muscular organ in humans and other animals, pumps blood through the vessels of the circulatory system. In medicine, a case report is a detailed report of symptoms, diagnosis, treatment and follow-up of an individual patient. Heart case report may contain a demographic profile of patient but usually describe an unusual or novel occurrence. Different case report can be done such as case reports on cardiac arrest and disea... Read More

Assessment of drug discontinuation among adult patients who are taking antiretroviral treatment at Yeka Sub-City Woreda 9 and 10 health centers Addis Ababa, Ethiopia

Image Assessment of drug discontinuation among adult patients who are taking antiretroviral treatment at Yeka Sub-City Woreda 9 and 10 health centers Addis Ababa, Ethiopia Background:  Antiretroviral  therapy  has  led  to  a  substantial  reduction  in  HIV-associated  morbidity and  mortality.  Efficacy  of  antiretroviral  treatment  in  HIV/AIDS  is  showing  inhibition  of  viral replication and reduction of viral load to a point where... Read More

Chronic Pulmonary Obstructive Disease

Image Chronic Pulmonary Obstructive Disease The chronic obstructive pulmonary disease remains to be a vital cause of morbidity and mortality in the world. It is a worldwide health problem, with cigarette smoking being a significant risk factor commonly; other causes, such as exposure to outdoor and indoor air pollution, work-related risks, and infections, are moreover important. It is a major public health problem which probable to rank fifth in 2020 as a global disease problem according to a study published by the World Bank/World Health Organization. In this review, t... Read More

Ophthalmology Case Reports: Open Access

Image Ophthalmology Case Reports is scheduled to celebrate its 4th anniversary in the year 2020. The journal is devoted to convey and spread to its researchers around the world, the latest knowledge in the field of Ophthalmology.  It is an open-access journal that caters reliable information for clinical Ophthalmologists, and others in the form of original articles, review articles, case reports, short communications, etc. and might want to disperse information through high impact articles in ophthalmology. The Journal offers this unique opportunity of greater flexibilit... Read More

New Era in Diagnosis of Kidney Disorders Via NGS

Image Next-generation sequencing (NGS) or high-throughput DNA sequencing is a DNA sequencing technology that has revolutionized genomic survey. It has a remarkable impact on the clinical practice and diagnosis of genetic disorders through the sequencing of the entire human genome including all coding genes. The speed and high-throughput of NGS enable clinicians to focus on the diagnosis of genetic disorders at a rate never before possible. However, currently, there are some challenges in the application of this valuable technology such as the complexity of data analysis and interpretation. ... Read More

Bilateral Obstructive Uropathy

Image Journal of Clinical Nephrology and Therapeutics publishes the manuscripts that are directly or indirectly based on variegated aspects of clinical nephrology, diabetic nephropathy, pediatric nephrology, renal physiology, renal histopathology, immunobiology, intensive care nephrology, and ischemic nephropathy. Treatment of obstructive uropathy is a common urological referral. The two treatment options are nephrostomy tube or ureteric stent insertion. Both are equally effective at providing collec... Read More

Invitro Fertilization in Infertile Patients with Endometrial Cancer

Image To assess the effectiveness of intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) and embryo transfer (IVF-ET) in infertile patients with early-stage endometrial cancer (EC) or atypical endometrial hyperplasia (AEH). Patients with well-differentiated, early-stage EC or AEH who achieved complete reversion of the endometrium after conservative treatment and who underwent IVF-ET between January 2012 and December 2015 were collected. The fertilization rate, implantation rate, pregnancy rate, and AEH/EC recurrence rate were measured. A total of 31 patient... Read More

Cardio-Nephrology

Image Journal of Clinical Nephrology and Therapeutics publishes the manuscripts that are directly or indirectly based on variegated aspects of clinical nephrology, diabetic nephropathy, pediatric nephrology, renal physiology, renal histopathology, immunobiology, intensive care nephrology, and ischemic nephropathy. Cardio-Nephrology: The need for more collaborative efforts between therapeutic clinical trials and social health sciences to preclude cardiovascular disease complications i... Read More

Journal of Public Health Policy and Planning Successful Journey

Image Journal of Public Health Policy and Planning is established in the year 2013,"Journal of Public Health Policy and Planning" and is overwhelmed by the response from the academic and research contributors to publish with the journal and to take part in the year-long celebrations.  It is one of the most reputed journals of Allied academies group, known for its strong association with various Alzheimer's societies and agencies engaged in cutting edge rese... Read More

Clinical and Therapeutic Treatment on Kidney Diseases

Image  Journal of Clinical Nephrology and Therapeutics is a peer-reviewed scientific open access journal that publishes original research articles, review articles, and clinical studies focusing on the prevention, diagnosis, and management of kidney diseases and associated disorders. It has a special emphasis on the needs of Clinical Nephrologists and those in developing countries. The journal publishes reviews and papers of international inte... Read More

Discount to Researchers for Article Processing Charges on 3rd Anniversary

Image Journal of Advanced Surgical Research (ISSN 2591-7765) commemorates its 3rd anniversary in the year 2020. Journal of Advanced Surgical Research is an upcoming journal that specializes in clinical surgical practices, researches, and teachings as well. This Journal majorly emphasizes the investigations or researches on surgical methods and analysis. It serves as a platform for academics, practitioners, regulators, and... Read More

Alarming the society on Kidney Diseases

Image Journal of Clinical Nephrology and Therapeutics is open access and peer-reviewed scientific journal. The journal serves as a bridge between scientific explorations and findings in the clinical field. And it also implementing the development of clinically applicable medical tools and techniques. Journal of Clinical Nephrology and Therapeutics publishes the manuscripts that are directly or indirectly based on variegated aspects o... Read More

Journal of Primary care and General Practice one step ahead in Protecting Life’s

Image Journal of Primary Care and General Practice is a peer-reviewed scientific publication that offers an open access forum to discuss the recent developments and innovative trends in the primary health care and general medical practice. Journal of Primary Care and General Practice, is established in the year 2018,"Journal of Primary Care and General Practice" and is overwhelmed by the response from the academ... Read More