This has prompted the development of new branch in Periodontology to be specific PerioMedicine. The idea of the relationship between the foundational infection and periodontal illness is viewed as bidirectional. Periodontal malady can be started or weakened by certain foundational infections yet can likewise start or disintegrate certain fundamental ailments. Periodontal ailments can create various changes in foundational wellbeing by changing the blood science with raised incendiary arbiters, proteins, lipids in serum. Hyperlipidemia and thyroid issue are connected with foundational aggravation. Periodontitis has been found to discharge provocative cytokines to foundational course. Along these lines, it could be connected with these two foundational conditions. The point is assurance of changes in periodontal status acquired by scaling and root anticipating serum lipid and thyroid profiles. PDF