We present a case report of a woman with a history of alcohol use disorder who was found to have both WernickeKorsakoff Syndrome (WKS) and Central Pontine Myelinolysis (CPM) on MRI. After a discussion of the case, we review the literature of the clinical manifestations, diagnostic criteria, and prognostic indicators of functional outcomes for both WKS and CPM. We compare and contrast the two diseases individually and simultaneously, as occurred in our patient. Central pontine myelinolysis (CPM) is a demyelinating disorder of the brainstem that typically occurs with the rapid correction of serum sodium in hyponatremic patients. Diagnosis of both WKS and CPM requires a high index of suspicion. Though overlapping in some aspects of clinical manifestations, the prognosis and functional outcomes can differ between the two diseases so it is important to distinguish between the two processes.